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    DiscoverX PI3-Kinase (p110alpha(E542K) p85alpha) murine 10 mcg 14-791
    品牌：Eurofins DiscoverX
    货号：14-791
    规格：14-791
    货期：DiscoverX
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    品牌：DiscoverX 品名：PI3-Kinase (p110α(E542K)/p85α) murine 货号：14-791 规格：10 µg
    商品详情 参考文献 相关资料

    品牌：DiscoverX
    品名：PI3-Kinase (p110α(E542K)/p85α) murine
    货号：14-791    
    规格：10 µg

    简要说明：

    PI3-Kinase (p110α(E542K)/p85α) murine

    Complex of N-terminal 6His-tagged recombinant, murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length. The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).


    产品介绍：

    Target
    PI3Kα/p85α
    Expression System
    Expressed by baculovirus in Sf21 insect cells
    Application
    Kinase Assay
    Molecular Weight
    129 kDa (p110α E542K), 84 kDa (p85α)
    Accession Number
    BC089038
    Species
    Mouse
    Tag
    6His
    Purification Method
    Ni2+/NTA-agarose
    Content
    Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
    Storage
    6 months at -70°C
    Bulk Sizes
    Inquire
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