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    DiscoverX Abl (Y253F), active 14-759M
    品牌：Eurofins DiscoverX
    货号：14-759M
    规格：14-759M
    货期：DiscoverX
    应用： 点击这里给我发消息  咨询客服

    品牌：DiscoverX 品名：Abl (Y253F), active 货号：14-759M 规格：250 µg
    商品详情 参考文献 相关资料
    品牌：DiscoverX
    品名：Abl (Y253F), active
    货号：14-759M 
    规格：250 µg

    简要说明：

    Abl (Y253F), active

    N-terminal 6His-tagged recombinant, human Abl, amino acids 27-end containing the Y253F mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Y253F mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).


    产品介绍：

    Target
    Abl
    Expression System
    Expressed by baculovirus in Sf21 insect cells
    Application
    Kinase Assay
    Molecular Weight
    121 kDa
    Accession Number
    U07563
    Species
    Human
    Tag
    6His
    Purification Method
    Ni2+/NTA-agarose
    Content
    Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.
    Storage
    6 months at -70°C
    Bulk Sizes
    Inquire

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