Catalogue number
PKA-075
Synonyms
Protein Tyrosine Phosphatase, Non-Receptor Type 4
(Megakaryocyte), Protein-Tyrosine Phosphatase MEG1, PTPase-MEG1, EC 3.1.3.48,
MEG, Tyrosine-Protein Phosphatase Non-Receptor Type 4, Megakaryocyte
Protein-Tyrosine Phosphatase, Protein Tyrosine Phosphatase MEG1, Megakaryocyte
Phosphatase, PTPMEG1, PTPMEG, Tyrosine-protein phosphatase non-receptor type 4,
Protein-tyrosine phosphatase MEG1.
Introduction
Protein Tyrosine Phosphatase Non Receptor Type-4, also known as PTPN4
belongs to the protein tyrosine phosphatase, PTP family. PTPs are identified as
signaling molecules which regulate a variety of cellular processes as well as
cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN4
is broadly expressed non-receptor protein tyrosine phosphatase. In addition, PTPN4
interacts with glutamate receptor delta 2 & epsilon, and affects glutamate
receptors signaling and/or in regulation of their activities through tyrosine dephosphorylation.
Description
PTPN4 Human Recombinant produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 280 amino acids (655-913 a.a) and having a
molecular mass of 32kDa.
PTPN4 is fused to a 21 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
E.coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
PTPN4 protein solution (1mg/ml) containing 20mM Tris
buffer (pH 8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MVLTQFDQLY RKKPGMTMSC AKLPQNISKN RYRDISPYDA TRVILKGNED YINANYINME
IPSSSIINQY IACQGPLPHT CTDFWQMTWE QGSSMVVMLT TQVERGRVKC HQYWPEPTGS SSYGCYQVTC
HSEEGNTAYI FRKMTLFNQE KNESRPLTQI QYIAWPDHGV PDDSSDFLDF VCHVRNKRAG KEEPVVVHCS
AGIGRTGVLI TMETAMCLIE CNQPVYPLDI VRTMRDQRAM MIQTPSQYRF VCEAILKVYE.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
