Catalogue number
ANT-473
Synonyms
ER-alpha
Type
Mouse anti-Estrogen Receptor Alpha (human and mouse).
Introduction
Estrogen receptors ? (ER?, ER; NR3A1) is a member of the steroid hormone receptor family. ER? is a ligand-activated transcription factor. ER? contain DNA binding and ligand binding domains. ER? is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. The natural ligand for ER is 17?-estradiol, the classical estrogenic compound. The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.
Clone
Immunogen
Recombinant human ER-alpha.
Ig Subclass
Mouse IgG.
Purification Method
Protein A.
Formulation
1mg/ml in PBS (after reconstitution).
Storage Procedures
Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
Solubility
Reconstitute with of H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Applications
Western Blot, Immunofluorescent Staining, Immunohistochemistry, flow cytometry, immunoprecipitation.
Available Conjugates
This antibody is only available as purified antibody.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
