Catalogue number
PRO-1890
Synonyms
TRAP-1, TRAP1, Transforming growth factor-beta receptor-associated
protein 1, TGF-beta receptor-associated protein 1.
Introduction
TGF-beta receptor-associated protein 1 also known
as TGFBRAP1 takes part in the TGF-beta/activin signaling pathway. TGFBRAP1 is
related with inactive heteromeric
TGF-beta and activin receptor complexes, mainly
through the type
II receptor, and is released
upon activation of signaling. TGFBRAP1recruits SMAD4 to the vicinity of the
receptor complex and smoothes the progress of its interaction with
receptor-regulated Smads, such as SMAD2.
Description
TGFBRAP1 Human Recombinant produced in E.Coli is a
single, non-glycosylated polypeptide chain containing 296 amino acids (601-860 a.a)
and having a molecular mass of 33kDa.
TGFBRAP1 is fused to a 36 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
TGFBRAP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 80% as determined by SDS-PAGE.
Amino acid sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKRLQ KEEYHTHLAV LYLEEVLLQR ASASGKGAEA TETQAKLRRL
LQKSDLYRVH FLLERLQGAG LPMESAILHG KLGEHEKALH ILVHELQDFA AAEDYCLWCS EGRDPPHRQQ
LFHTLLAIYL HAGPTAHELA VAAVDLLNRH ATEFDAAQVL QMLPDTWSVQ LLCPFLMGAM RDSIHARRTM
QVALGLARSE NLIYTYDKMK LKGSSIQLSD KKLCQICQNP FCEPVFVRYP NGGLVHTHCA ASRHTNPSSS
SPGTRT
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
