Catalogue number
PRO-2162
Synonyms
Folate Receptor 1 (Adult), Ovarian Tumor-Associated Antigen MOv18, Adult Folate-Binding Protein, Folate Receptor Adult , KB Cells FBP, FR-Alpha, FOLR, FBP, Folate Binding Protein, Folate Receptor Alpha, Folate Receptor 1.
Introduction
Folate
Receptor 1, also known as FOLR1, is a part of the folate receptor family whose
members bind folic acid. FOLR1 binds to folate and reduced
folic acid derivatives and facilitates transfer of 5-methyltetrahydrofolate and
folate analogs into the cells. FOLR1
is either attaches to membranes through a glycosyl-phosphatidylinositol linkage
or exists in a soluble form. FOLR1 is also needed for embryonic
development and normal cell proliferation.
Description
FOLR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (25-234 a.a) and having a molecular mass of 27kDa. FOLR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
FOLR1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSRIAWART ELLNVCMNAK HHKEKPGPED KLHEQCRPWR KNACCSTNTS QEAHKDVSYL YRFNWNHCGE MAPACKRHFI QDTCLYECSP NLGPWIQQVD QSWRKERVLN VPLCKEDCEQ WWEDCRTSYT CKSNWHKGWN WTSGFNKCAV GAACQPFHFY FPTPTVLCNE IWTHSYKVSN YSRGSGRCIQ MWFDPAQGNP NEEVARFYAA AMS.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
