Catalogue number
PRO-321
Synonyms
UTI, Ulinastatin, Urinary Trypsin Inhibitor.
Introduction
Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor which inhibits the activity of trypsin, chymotrypsin, lactate, lipase, hyaluronidase and various pancreatic enzymes. Ulinastatin is effective for acute pancreatitis, chronic recurrent pancreatitis and hemorrhagic, traumatic and endotoxic shocks. Ulinastatin is has strong inhibition effect to various protease, sugar and fat hydrolase. Ulinastatin precursor is proteolytically processed into distinct functioning proteins. Urinary trypsin inhibitor belongs to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. Uristatin gene is located on chromosome 9 in a cluster of lipocalin genes.
High levels of Ulinastatin secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane.
Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. UTI has a calculated Mw of approx. 20kDa and 40kDa by SDS-PAGE analysis.
Ulinastatin particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte.
Description
Ulinastatin is derived from human urine.
Source
Human Urine.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a (1mg/ml) solution containing no additives.
Solubility
It is recommended to reconstitute the lyophilized UTI in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability
Store the lyophilized UTI between 2-8°C, do not freeze.
Upon reconstitution UTI should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.
Biological Activity
Human UTI has an activity of 2350IU/mg.
References
Title: Ulinastatin as a Potential Alternative Therapy for
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Publication: "Journal of Asian Medical Students'' Association 4.1 (2015):
25-39.
Link: http://www.j-amsa.amsa-international.org/index.php/main/article/view/75/52
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
