Catalogue number
ANT-511
Synonyms
Snail
Family Zinc Finger 1, Protein Sna, Protein Snail Homolog 1, SNAH, Snail 1
(Drosophila Homolog), Zinc Finger Protein, Snail Homolog 1 (Drosophila),
SLUGH2, SNA, SNAIL, SNAIL1, dJ710H13.1, Snail 1 Homolog, Snail 1 Zinc Finger
Protein, Snail 1, Zinc Finger Protein, Snail Homolog 1, Zinc Finger Protein
SNAI1.
Type
Mouse Anti Human Monoclonal.
Introduction
Snail homolog 1 (SNAI1) is involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. SNAI1 binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. The nuclear protein encoded by SNAI1 is structurally identical to the Drosophila snail protein, and is considered as well to be vital for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.Among the diseases associated with SNAI1 are waardenburg syndrome type iid, and inappropriate adh syndrome.
Clone
PAT2D5AT.
Physical Appearance
Sterile filtered colorless solution.
Immunogen
Anti-human SNAI1 mAb,
clone PAT2D5AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human SNAI1 protein 1-264
amino acids purified from E. coli.
Ig Subclass
Mouse
IgG2b heavy chain and k light chain.
Purification Method
SNAI1 Antibody was purified from mouse ascitic fluids by
protein-A affinity chromatography.
Formulation
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Storage Procedures
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C.
Prevent freeze thaw cycles.
Stability / Shelf Life
12 months at -20°C. 1 month at 4°C.
Applications
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:1000.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
