Catalogue number
ANT-097
Type
Mouse antibody Monoclonal.
Introduction
Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
Clone
PPT10E11VN.
Immunogen
r.HBcAg Core ayw Antigen.
Ig Subclass
Specificity
HBcAg Core Antigen.
Formulation
1mg/ml in 0.01% sodium azide.
Epitope
80 a.a. (Major Antigenic Determinant).
Physical Appearance
Sterile Filtered solution.
Shipping Conditions
Antibody is shipped as in liquid form with ice packs.
Storage Procedures
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Safety Data Sheet
Applications
ELISA, WB, IHC.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
