Catalogue number
PRO-2262
Synonyms
CD69
Molecule, CD69 Antigen (P60, Early T-Cell Activation Antigen), Early T-Cell
Activation Antigen P60, Leukocyte Surface Antigen Leu-23, BL-AC/P26, GP32/28, CLEC2C,
MLR-3, AIM, EA1, C-Type Lectin Domain Family 2, Member C, Activation Inducer
Molecule (AIM/CD69), C-Type Lectin Domain Family 2 Member C, Early Lymphocyte
Activation Antigen, Activation Inducer Molecule, CD69 Antigen, Early activation
antigen CD69.
Introduction
CD69 is a type 2 transmembrane glycoprotein which belongs to the C-type
lectin family. CD69 is a very early activation Ag of T lymphocytes. The expression
of CD69 is induced upon activation of T lymphocytes, and CD69 takes part in
proliferation. Moreover, CD69 acts to transmit signals in natural killer cells
as well as platelets. CD69 functions in the pathogenesis of allergen induced eosinophilic
airway inflammation and responsiveness. Among the diseases which are associated
with CD69: cd3gamma deficiency and mast cell disease.
Description
CD69 produced in Sf9 Baculovirus cells is a single,
glycosylated polypeptide chain containing 147 amino acids (62-199a.a.) and
having a molecular mass of 17.0kDa.
(Molecular size on SDS-PAGE will appear at
approximately 18-28kDa).
CD69 is expressed with a 6 amino acid His tag at
C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,
Baculovirus cells.
Physical Appearance
Sterile Filtered clear solution.
Formulation
CD69 protein solution (0.5mg/ml) contains Phosphate
Buffered Saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence
ADPSVGQYNC PGQYTFSMPS
DSHVSSCSED WVGYQRKCYF ISTVKRSWTS AQNACSEHGA TLAVIDSEKD MNFLKRYAGR EEHWVGLKKE PGHPWKWSNG
KEFNNWFNVT GSDKCVFLKN TEVSSMECEK NLYWICNKPY KHHHHHH.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
