Catalogue number
PRO-1731
Synonyms
Heterogeneous Nuclear Ribonucleoprotein A/B, ABBP-1, ABBP1,
APOBEC1-Binding Protein 1, HnRNP A/B, Apobec-1 Binding Protein 1, Apolipoprotein
B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1, HnRNP Type
A/B Protein.
Introduction
Heterogeneous Nuclear Ribonucleoprotein A/B
(HNRNPAB) is a member of the subfamily of ubiquitously expressed heterogeneous
nuclear ribonucleoproteins
(hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of
theheterogeneous nuclear RNA (hnRNA) complexes. They are linked with pre-mRNAs
in the nucleus and seem to influence pre-mRNA processing and further aspects of
mRNA metabolism and transport. Whereas all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct
nucleic acid binding properties. HNRNPAB, which binds to one of the components
of the multiprotein editosome
complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind
to RNAs. Among the diseases associated with HNRNPAB
are wells syndrome, and cystic fibrosis.
Description
HNRNPAB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285 a.a) and having a molecular mass of 33kDa.
HNRNPAB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
HNRNPAB
protein solution (0.25mg/ml) containing 30% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMSEAGEE QPMETTGATE NGHEAVPEGE SPAGAGTGAA AGAGGATAAP PSGNQNGAEG
DQINASKNEE DAGKMFVGGL SWDTSKKDLK DYFTKFGEVV DCTIKMDPNT GRSRGFGFIL FKDAASVEKV
LDQKEHRLDG RVIDPKKAMA MKKDPVKKIF VGGLNPEATE EKIREYFGEF GEIEAIELPM DPKLNKRRGF VFITFKEEEP
VKKVLEKKFH TVSGSKCEIK VAQPKEVYQQ QQYGSGGRGN RNRGNRGSGG GGGGGGQGST NYGKSQRRGG
HQNNYKPY
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
