Catalogue number
PRO-1750
Synonyms
Modulator
Of Apoptosis 1, MAP1, PNMA4, Paraneoplastic Ma Antigen Family Member 4, Paraneoplastic
Antigen Ma4, MAP-1, Paraneoplastic Antigen Like 4.
Introduction
Modulator
of apoptosis 1 (MOAP1), is a member of the PNMA family and contains one BH3-like domain
and one RASSF1-binding domain. MOAP1 was recognized by its interaction with
apoptosis regulator BAX protein. MOAP1 includes a Bcl-2 homology 3 (BH3)-like
motif, which is essential for the association with BAX. In addition, once over
expressed MOAP1 mediates caspase-dependent apoptosis.
Description
MOAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 374 amino acids (1-351a.a) and having a molecular mass of 41.9kDa.
MOAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
MOAP1 protein solution (0.5mg/ml) containing 20mM
Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMTLRLLE DWCRGMDMNP RKALLIAGIS QSCSVAEIEE ALQAGLAPLG EYRLLGRMFR RDENRKVALV GLTAETSHAL VPKEIPGKGG IWRVIFKPPD PDNTFLSRLN EFLAGEGMTV GELSRALGHE NGSLDPEQGM IPEMWAPMLA QALEALQPAL
QCLKYKKLRV FSGRESPEPG EEEFGRWMFH TTQMIKAWQV PDVEKRRRLL ESLRGPALDV IRVLKINNPL ITVDECLQAL EEVFGVTDNP RELQVKYLTT YQKDEEKLSA YVLRLEPLLQ KLVQRGAIER DAVNQARLDQ VIAGAVHKTI RRELNLPEDG PAPGFLQLLV LIKDYEAAEE
EEALLQAILE GNFT
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
