Catalogue number
PRO-2185
Synonyms
C-Type Lectin Domain Family 1, Member B, CLEC2, C-Type
Lectin-Like Receptor 2, CLEC2B, CLEC-2, C-Type Lectin Domain Family 1 Member B,
C-Type Lectin-Like Receptor-2, 1810061I13Rik, PRO1384, QDED721, C-type lectin
domain family 1 member B, C-type lectin-like receptor 2.
Introduction
C-type
Lectin Domain Family 1 Member B, also known as CLEC1B. NK-Natural killer cells
express multiple calcium-dependent (C-type) lectin-like receptors, for instance
CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), which interact with
major histocompatibility complex class I molecules and either inhibit or else
activate cytotoxicity and cytokine secretion. CLEC1B is a C-type lectin-like
receptor which is expressed in myeloid cells as well as in NK cells.
Description
CLEC1B Human Recombinant produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 198 amino acids (55-229 a.a) and having a
molecular mass of 23.1kDa.
CLEC1B is fused to a 23
amino acid His-tag at N-terminus & purified by proprietary chromatographic
techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CLEC1B protein solution (1mg/ml) containing 20mM Tris, PH
8.0 and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSSVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP
CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK
WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
