Catalogue number
PRO-342
Synonyms
Troponin T cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2, CMH2, CMPD2, MGC3889.
Introduction
Troponin-T is one of three subunits that form the troponin complex of the thin filaments of striated muscle, it regulates muscle contraction in response to alterations in intracellular calcium ion concentration. TnTc is expressed only in the heart and has proved to be a specific biomarker for heart disease.
Mutations in TNNT2 are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy.
Alternative splicing results in many tissue-specific isoforms.
Description
Human Cardiac Troponin T produced from Human Cardiac Tissue, having a molecular weight of approximately 35 kDa.
The Cardiac troponin-T is purified using a combination of ion-exchange and affinity chromatography steps.
Source
Human Cardiac Tissue.
Physical Appearance
Sterile Filtered colorless liquid formulation.
Formulation
Human Cardiac Troponin T in 6M Urea, 250mM NaCl, 50mM Tris-HCl, 15mM b-mercaptoethanol, 1mM EDTA, pH-7.2.
Stability
Human TnT although stable at 10°C for 7 days, should be stored below -18°C.
Please prevent freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Human Virus Test
Blood samples from tissue donors used in the manufacture of this product tested negative for HIV-1,2, HbsAg, HCV and RPR/STS.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
