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 PE - anti human CD79a - Clone HM57 |产品详情|进口橙子视频旧款采购网




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    PE - anti human CD79a - Clone HM57
    品牌：Immunostep
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    PE - anti human CD79a - Clone HM57
    商品详情 参考文献 相关资料

    PE - anti Human CD79a - HM57

    Reference Size Price Quantity Add to cart
    79APE-100T 100 test
    260,00 € tax excl.

    Product Description

    • HM57
    • IgG1
    • FCM
    • PE
    • Please refer to the Certificate of Analysis for the lot-specific concentration.
    • Synthetic peptide corresponding to 202-216 amino acid sequence of human mb-1.
    • Human
    • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
    • RUO
    • CD79a, clone HM57, is a mAb intended for the identification of B lymphocytes. This reagent is effective for direct iIF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
    CD79a View larger
    • CD79a
    • CD79a

    This antibody reacts with the CD79a-antigen. CD79a associates with CD79b to form part of the B-cell receptor complex. It has been suggested that CD79a may play a role in mediating the transport of IgM to the cell surface. This antibody has been found to react on permeabilized A20 cells (mouse B cell line). CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
    • Mb-1, Ig?
    • 973
    • 47 kDa
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