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Phospho-MKP-1/2 (Ser296/318) Antibody detects endogenous levels of MKP-1/2 only when phosphorylated at Serine 296/318. The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/S-protein phosphatase encoded by the late gene H1 of vaccinia virus.

Target	MKP-1/2 (pS296/318)
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthesized peptide derived from human MKP-1/2 around the phosphorylation site of Serine 296/318.
Purification	Immunogen affinity purified.
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	45 kDa
Swiss Prot	P28562 Q13115
Enzyme Commission Number	EC 3.1.3.16, EC 3.1.3.48
Buffer	Rabbit IgG in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.