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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	PRDM2 (RIZ1)
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Tested Applications	ChIP
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human PRDM2 (RIZ1).
Purification	Purified Mouse Monoclonal Antibody.
Isotype	IgG1
Conjugation	Unconjugated
Specificity	Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	Q13029
NCBI Accession	NP_001007258.1 NP_001129082.1 NP_036363.2 NP_056950.2
Buffer	PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.