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NBN Antibody abx000860|产品详情|进口橙子视频旧款采购网




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    NBN Antibody
    品牌:
    货号:abx000860
    规格:10 μl
    货期:

    NBN Antibody

    商品详情 参考文献 相关资料
    NBN Antibody is a Rabbit Polyclonal antibody against NBN. NBN, also named as NBS, NBS1 and P95, is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosesis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. Defects in NBN are the cause of Nijmegen breakage syndrome (NBS). Defects in NBN are a cause of genetic susceptibility to breast cancer (BC). Defects in NBN may be associated with aplastic anemia. Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The antibody is specific to NBN.

    Target NBN
    Reactivity Human, Mouse
    Origin Human
    Host Rabbit
    Clonality Polyclonal
    Tested Applications WB
    Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
    Immunogen A synthetic peptide of human NBN.
    Purification Affinity purified.
    Form Liquid
    Isotype IgG
    Conjugation Unconjugated
    Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
    Molecular Weight Calculated MW: 84 kDa
    Observed MW: 95 kDa
    Swiss Prot O60934
    GeneID 4683
    Gene Symbol NBN
    Concentration > 1 mg/ml
    Buffer PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
    Availability Shipped within 5-10 working days.
    Note This product is for research use only.
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