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This antibody reacts with CD45RC on pre-B lymphocytes,B cells,CD8+ T suppressor/cytotoxic cells,and a subset of CD4+ T helper (Th)lymphocytes. It weakly reacts with thymocytes.4 CD45RC is a high-molecular-weight isoform of CD45 (Leukocyte Common Antigen);its level of expression distinguishes subpopulations of CD4 +T cells with Th1-like and Th2-like effector functions. Levels of expression of CD45RC have also been reported to distinguish resting from activated T cells at various stages of maturation. CD45 is a member of the Protein Tyrosine Phosphatase (PTP)family:Its intracellular (COOH-terminal)region contains two PTP catalytic domains,and the extracellular region is highly variable due to alternative splicing of exons 4,5,and 6 (designated A,B,and C,respectively),plus differing levels of glycosylation. The CD45 isoforms detected in the rat are cell type-,maturation-,and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

Target	CD45RC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Cells CD45+ of healtly donors.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	APC
Specificity	It is used for the differential diagnosis of nonHodgkin lymphomas. It also reacts with T suppressor/cytotoxic cells and NK cells.Their functional activity may be related to the induction of suppressor or cytotoxic activity, and activation processes.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	220 kDa
Swiss Prot	P08575
GeneID	5788
Enzyme Commission Number	EC 3.1.3.4
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 2-3 weeks.
Note	This product is for research use only.