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 EGFR (pY1125) Antibody abx031963|产品详情|进口橙子视频旧款采购网




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    EGFR (pY1125) Antibody
    品牌:
    货号:abx031963
    规格:80 μl
    货期:

    EGFR (pY1125) Antibody

    商品详情 参考文献 相关资料
    EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

    Target EGFR (pY1125)
    Reactivity Human
    Host Rabbit
    Clonality Polyclonal
    Tested Applications DB
    Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
    Immunogen Human EGFR (phospho-Tyr1125).
    Purification Peptide Affinity Purified Rabbit Polyclonal Antibody.
    Isotype IgG
    Conjugation Unconjugated
    Specificity This EGFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1125 of human EGFR.
    Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
    Swiss Prot P00533
    Buffer PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Availability Shipped within 5-10 working days.
    Note This product is for research use only.
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