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The monoclonal antibody is directed against the CD21-antigen, which is expressed on normal Ig-positive B-cells from peripheral blood and lymphoid tissues and on dendritic cells of germinal centres. Its expression is lost on activated B-cells. The distinct distribution among B-cell malignancies differs from other B-cell markers e.g. CD19 and CD20

Target	CD21
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Tissue / cell preparation (Human).
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG2a
Conjugation	CF-Blue
Specificity	CD21 is expressed on B cells, follicular dendritic cells, subsets of normal thymocytes and T cells, and some epithelial cells. CD21 is the receptor used by Epstein-Barr virus to infect B cells and is also the complement receptor for C3d. CD21 has also been shown to interact with a number of proteins, including CD23, CD19, annexin VI, CD81, iC3b, complement receptor 1 (CR1, CD35), and interferon-alpha 1 (IFN-α1).
Storage	Store in the dark at 2-8 °C.
Molecular Weight	145 kDa
Swiss Prot	P20023
GeneID	1380
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 3-5 working days.
Note	This product is for research use only.