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The CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells. CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in T cell-B cell interactions. It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from those stimulated by the TCR complex. Additionally, it has been reported that CD28 antibody clones vary in their ability to stimulate T cells to produce IL-2 and increase intracellular Ca2+ concentration. This finding suggests the existence of functionally distinct subregions on the CD28 molecule. CD28.2 has been demonstrated to bind to the same molecule as clone L293, another CD28 mAb, and has been reported to induce Ca2+ influx in Jurkat T cells.

Target	CD28
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human CD28 Transfected Cell Line.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	FITC
Specificity	The monoclonal antibody is directed against the CD28 antigen, which is weakly expressed on human T cells in the resting period and strongly on human cytotoxic/suppressor T cells (molecular mass 44 kDa). The antibody also reacts with 30% of human thymocytes and ***** cell leukaemia. It does not react with normal human B lymphocytes, monocytes, granulocytes, platelets, erythrocytes, common acute lymphoblastic leukaemia cells or acute myelocytic leukaemia cells.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	44 kDa
Swiss Prot	P10747
GeneID	940
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 3-5 working days.
Note	This product is for research use only.