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Reacts with a homodimeric integral membrane protein comprised of 95Kd subunits (CD105). CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and ***** bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.

Target	CD105
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human Endoglin fusion protein.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	Biotin
Specificity	Endoglin is an endothelial homodimeric membrane antigen containing the tripeptide sequence RGD, which is a recognition motif for adhesion receptors of the integrin family. It has been proposed that endoglin is a TGF-b receptor. Endoglin is a glycoprotein present on endothelial cells of capillaries, arterioles and venules in a variety of tissues and at low levels on acute lymphoblastic and myelocytic leukaemia cells.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	95 kDa
Swiss Prot	P17813
GeneID	2022
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 2-3 weeks.
Note	This product is for research use only.