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IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons.  All three IFN-lambdas use a distinct receptor system composed of an IFN- λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14).  Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons.  Recombinant Murine IFN- λ2 is a 19.8 kDa protein containing 175 amino acid residues.

Source: E.coli

Synonyms: IL-28A

AA Sequence: MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAevals TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction.