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PlGF-2  is  an  angiogenic  factor  that  belongs  to  the  cysteine-knot  superfamily  of  growth  factors.    PlGF-2  is  expressed  in  umbilical  vein  endothelial  cells  and  placenta.    It  signals  through  the  VEGFR-1/FLT1  receptor,  and  stimulates  endothelial  cell  proliferation  and  migration.    PlGF-2  also  signals  through  Neuropilin  (NP-1),  and  can  bind  with  high  affinity  to  heparin.  Recombinant  Human  PlGF-2  is  a  34.6  kDa  disulfide-linked  homodimeric  protein  of  two  152  amino  acid  polypeptide  chains.

Source: E.coli

Synonyms: Placenta Growth Factor-2, PGFL

AA Sequence (monomer): LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human THP-1 cells of using a concentration range of 5.0-50.0 ng/ml.