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FGF-10 is a heparin-binding growth factor that belongs to the FGF family.  Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.  FGF-10 is most related to KGF/FGF-7, and is expressed during the development and, preferentially, in ***** lungs.  It signals through the FGFR 2b.  Recombinant Human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2

AA Sequence: MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.  The expected ED₅₀ is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.