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Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum |产品详情|进口橙子视频旧款采购网




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    Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum
    品牌:Badrilla
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    Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum

    商品详情 参考文献 相关资料
    Ryanodine receptor 2 western blot

    Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum

    $599.00

    In stock

    Product code: A010-30
    Unit Size: 50 µl
    • Description
    • Data Sheet

    A fully validated, highly specific rabbit polyclonal antibody to Ryanodine Receptor 2 phospho Serine-2808

    The Ryanodine Receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+  to ryanodine receptor 2 (RyR2) opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. Abnormal structure and function of ryanodine receptors has been reported in failing hearts, with Ser-2808 phosphorylation appearing elevated in clinical situations which may contribute to the abnormal Ca2+ handling characteristics of cardiac muscle in these conditions. Ser-2808 can be phosphorylated in vitro by PKA or CaMKII, which is coincident with significant change in ryanodine receptor 2 RyR2 channel function typified by an increased open probability, the abrogation of the inhibitory effects of CaM, and Mg2+, dissociation of regulatory factors, expression of subconductance states and the expression of channel activity at diastolic Ca2+ concentrations. Serine-2808 in human RyR2 equates to Ser-2809 in rabbit RyR2.

    Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution). Species recognition: human, rat, mouse, rabbit, dog, canine and sheep.

     
    Description Lyophilised Rabbit polyclonal serum containing IgG antibody specific to RyR2 Phospho Ser-2808.
    Immunogen Synthetic peptide (YNRTRRIS(PO3H2)QT2810) conjugated to keyhole limpet haemocyanin.
    Isotype IgG
    Purification Raw serum
    Species reactivity The antibody recognises phosphorylated Serine-2808 of the ryanodine receptor and binding is blocked in the presence of a peptide containing the Phospho Ser-2808 epitope.
    Tested applications WB, IHC, ELISA
    Recommended dilution WB 1:5000, IHC 1:100
    Optimization Optimal dilutions to be determined by end user
    Storage Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
    Storage Lyophilised: 4 °C Reconstituted:-80 °C
    Datasheet A010-30 Lot 1209-03



    A010-30 Lot 0212-03

    MSDS A010-30

    Regulatory statement Product for research use only. Not intended for diagnostic or therapeutic use.
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