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Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (K = 10 nM for mClk1/Sty; IC= 20 nM, 200 nM, 10 M, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively). Recently, it has been shown that TG003 promotes the skipping of exon 31 in the endogenous dystrophin gene in a dose-dependent manner and increases the production of the dystrophin protein.

Additional Information

Synonyms	(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
Product #	T-2456
CAS #	300801-52-9
Chemical Name	(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
Formula	C13H15NO2S
MW	249.33
Appearance	Pale yellow Solid
Purity	98% by TLC
Solubility	Soluble in DMSO (30 mg/ml)
Storage Temp	-20°C
Use	Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk)

Additional Information

MDL Number	MFCD00624584
ChemACX	X1460813-4
InChI	InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
SMILES	CCN1c2cc(ccc2S/C1=CC(=O)C)OC