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(S)-(+)-Rolipram

品牌：AG Scientific

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CAS:85416-73-5Formula:C16H21NO3MW:275.35Appearance:SolidPurity:>99%

商品详情参考文献相关资料

Less active enantiomer of (RS)-Rolipram. Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.

*Also See R1012 (R,S) Rolipram or R-1013 (R) Rolipram.

Additional Information

Product #	R-1203
CAS #	85416-73-5
Chemical Name	(S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Formula	C₁₆H₂₁NO₃
MW	275.35
Appearance	Solid
Purity	>99%
Solubility	Soluble to 100mM in DMSO
Melting Point	128-129 °C
Storage Temp	Store at + 4 °C under desiccating conditions.
Use	Used in Neurodegenrative Disease research as a PDE4 inhibitor.

Additional Information

MDL Number	MFCD03093861
ChemACX	X1461533-5
InChI	InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
SMILES	COc1ccc(cc1OC2CCCC2)[C@@H]3CC(=O)NC3

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