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Tyrphostin, AG 490

品牌：AG Scientific

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规格：5 mg

货期：

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CAS:133550-30-8Formula:C17H14N2O3MW:294.3Appearance:TanSolidPurity:≥98%

商品详情参考文献相关资料

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells,which abundantly express JAK-2, AG-490 dosedependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 μM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinaseactivity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Additional Information

Synonyms	Tyrphostin B42, a-Cyano-(3,4- dihydroxy)-]N-benzylcinnamamide
Product #	A-1164
CAS #	133550-30-8
Chemical Name	N-Benzyl-3,4-dihydroxy-benzylidene
Formula	C₁₇H₁₄N₂O₃
MW	294.3
Appearance	Tan Solid
Purity	≥98%
Solubility	Soluble in DMSO (25mg/ml) or methanol (10mg/ml).
Storage Temp	-20°C