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Thapsigargin, ER stress inducer

品牌：AG Scientific

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规格：1 mg

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CAS:67526-95-8Formula:C34H50O12MW:650.8Appearance:Whitetooff-whitelyophilizedpowderPurity:99.8%

商品详情参考文献相关资料

Thapsigargin is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Thapsigargin increases cytosolic calcium levels through release from intracellular calcium stores. Depletion of ER calcium stores leads to Ca²⁺ influx via activation of store (voltage)-operated calcium channels in the plasma membrane, mediating numerous physiological functions, including exocytosis, chemotaxis, transcription, cell division, and apoptosis. There are preclinical indications that the drug may have anticancer potential.

According to a recent paper Thapsigargin indirectly and robustly inhibits nonsense-mediated RNA decay (NMD), and this potential of thapsigargin has been harnessed to develop a method that detects NMD efficiency inside the cell.

Additional Information

Synonyms	thaps, tg
Product #	T-1014
CAS #	67526-95-8
Chemical Name	[(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL] OCTANOATE
Formula	C₃₄H₅₀O₁₂
MW	650.8
Appearance	White to off-white lyophilized powder
Purity	99.8%
Solubility	Clear and colorless solution at 10 mg/mL of CH₃CN
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase

Additional Information

Merck Index	Merck Index: 13.9342
MDL Number	MFCD00083511
ChemACX	X1096797-0
InChI	InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
SMILES	CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O