14-Hydroxyfilipin (Lagosin) |产品详情|进口橙子视频旧款采购网

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14-Hydroxyfilipin (Lagosin)

品牌：AG Scientific

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规格：1 mg

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CAS:6834-98-6Formula:C35H58O12MW:670.4Appearance:PaleyellowtotansolidPurity:>95%byHPLC

商品详情参考文献相关资料

Lagosin or 14-HYDROXYFILIPIN is a pentaene antifungal antibiotic produced by Streptomyces. It was first isolated in 1958 by researchers at MIT in the USA. Lagosin exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols.Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides.

In a recent study 14-HYDROXYFILIPIN was used to evalsuate its efficacy on candida albicans biofilm formation. The results revealed that 14-HYDROXYFILIPIN has an inhibitory effect on the formation of C. albicans biofilm in a dose-dependent manner with a minimum inhibitory concentration (MIC) of 10 µg/mL. It also showed that 14-HYDROXYFILIPIN could also induce the apoptosis of C. albicans cells in a dose-dependent manner.

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Additional Information

Synonyms	Fungichromin, Lagosin, Cogomycin, Moldcidin B, A246, Pentamycin
Product #	L-2525
CAS #	6834-98-6
Formula	C₃₅H₅₈O₁₂
MW	670.4
Appearance	Pale yellow to tan solid
Purity	>95% by HPLC
Therapeutic Area	Infectious Diseases
Use	Lagosin exhibits broad spectrum antifungal and antitumor activity

Additional Information

MDL Number	MFCD01939601
InChI	InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+
SMILES	CCCCCC(C1C(CC(CC(CC(CC(CC(C(C(/C(=C/C=C/C=C/C=C/C=C/C(C(OC1=O)C)O)/C)O)O)O)O)O)O)O)O)O

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