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Bafilomycin A1

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:88899-55-2Formula:C35H58O9MW:622.8Appearance:Whitesolid(Lyophilized)Purity:>98%

商品详情参考文献相关资料

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Post-endocytic sorting of calcitonin Receptor-like Receptor and Receptor Activity-Modifying Protein 1. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

The inhibitors that act on the late stage of autophagy include chloroquine (CQ), bafilomycin A1, leupeptin, and pepstatin. These latter compounds either inhibit the fusion of autophagosomes with lysosomes or the degradation of autolysosomes.

Additional Information

Synonyms	Baf-A1, Baf A
Product #	B-1183
CAS #	88899-55-2
Chemical Name	(2Z,4E,6R,7S,8S,10E,12E,14S,15R)-15-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-DIHYDROXY-5-METHYL-6-PROPAN-2-YLOXAN-2-YL]-3-HYDROXYPENTAN-2-YL]-7-HYDROXY-2,14-DIMETHOXY-4,6,8,10-TETRAMETHYL-16-OXACYCLOHEXADECA-2,4,10,12-TETRAEN-1-ONE
Formula	C₃₅H₅₈O₉
MW	622.8
Appearance	White solid (Lyophilized)
Purity	>98%
Solubility	Soluble in ethanol, methanol, DMF or DMSO. DMSO at 50mg/ml. Poor water solubility. NOTE: Forms methyl ketal on long term storage in methanol.
Storage Temp	Store desiccated at -20°C max 3 yrs as powder, -80 for 2 yrs as solvent.
Therapeutic Area	Oncological Disorders
Use	Bafilomycin A1 inhibit macroautophagy and promote apoptosis in colon cancer cells . Baf A1 inhibits the action of Tentanus toxin in spinal cord neurons in cell culture. It also inhibits rhinovirus infection in human airways

Additional Information

MDL Number	MFCD06795130
ChemACX	X1087211-6
InChI	InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
SMILES	C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C

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