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Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds. Cytotoxic secondary metabolite (IC50=50 pg/ml in mouse cell line L929) That arrests tumor cell in the G1 phase at remarkably low concentrations (50 pg/ml in HeLa cell line KB3.1). More potent than leptomycin B and specific for G1/S checkpoint. Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound.

Additional Information

Product #	R-1128
CAS #	163564-92-9
Chemical Name	(1S,5S)-1,5-ANHYDRO-2,4-DIDEOXY-5-((1R,2E,4E,7R,8Z,10E)-1-HYDROXY-5,7,9-TRIMETHYL-11-[(2R)-6-OXO-3,6-DIHYDRO-2H-PYRAN-2-YL]UNDECA-2,4,8,10-TETRAEN-1-YL)-2-METHYL-1-[(1E)-PROP-1-EN-1-YL]-D-THREO-PENTITOL
Formula	C25H40O50
MW	456.6
Appearance	Liquid
Purity	95%
Solubility	Soluble in methanol(20mg/ml) or aqueous buffers up to 100uM.
Preparation	Shipped on dry ice. Acid and base sensitive. Unstable in acidic buffer systems (pH<6). Stable in substance as an oil and in solution in methanol at -20°C.
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

Additional Information

MDL Number	MFCD06412380
ChemACX	X1862225-0
InChI	InChI=1S/C28H40O5/c1-6-9-26-22(5)25(30)18-27(33-26)24(29)12-7-10-19(2)16-21(4)17-20(3)14-15-23-11-8-13-28(31)32-23/h6-10,12-15,17,21-27,29-30H,11,16,18H2,1-5H3/b9-6+,12-7+,15-14+,19-10+,20-17-/t21-,22+,23-,24-,25-,26+,27+/m1/s1
SMILES	O=C2O[C@@H](/C=C/C(=C[C@H](C)CC(=CC=C[C@@H](O)[C@H]1O[C@@H](/C=C/C)[C@H]([C@H](O)C1)C)C)C)C/C=C/2