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MS-275, HDAC inhibitor

品牌：AG Scientific

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规格：25 mg

货期：

应用：

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CAS:209783-80-2Formula:C21H20N4O3MW:376.42Appearance:PaleyellowsolidPurity:98%byTLCNMR(Conforms)

商品详情参考文献相关资料

MS-275 (209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC₅₀ = 300 nM) over HDAC3 (IC₅₀ = 8 μM) and HDAC8 (IC₅₀ 100 μM). In vivo, MS-275, has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin and to block cell proliferation in a variety of cancer cell lines. MS-275 has also shown significant anti-rheumatic activity in rat and mouse arthritis models.

Additional Information

Synonyms	Entinostat
Product #	M-3331
CAS #	209783-80-2
Formula	C₂₁H₂₀N₄O₃
MW	376.42
Appearance	Pale yellow solid
Purity	98% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (up to 25 mg/ml).
Storage Temp	-20°