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MK-2206

品牌：AG Scientific

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规格：500 ug

货期：

应用：

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CAS:1032350-13-2Formula:C25H21N5O.2HClMW:480.39Appearance:CrystallinesolidPurity:≥98%byHPLC

商品详情参考文献相关资料

A highly selective non-ATP competitive allosteric Akt inhibitor with IC₅₀’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³⁰⁸ and Ser⁴⁷³ in 3T3-L1 adipocytes with IC₅₀ values of 0.11 and 0.18 µM, respectively as well as downstream effects of insulin on GLUT4 translocations (IC₅₀ = 0.47 µM) and glucose transport (IC₅₀ = 0.14 µM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G.

Additional Information

Product #	M-2382
CAS #	1032350-13-2
Chemical Name	8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Formula	C₂₅H₂₁N₅O .2HCl
MW	480.39
Appearance	Crystalline solid
Purity	≥98% by HPLC
Solubility	DMSO
Storage Temp	-20°C