Stauprimide, Streptomyces sp., | CAS[154589-96-5] | Semi-synthetic |产品详情|进口橙子视频旧款采购网

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Stauprimide, Streptomyces sp., | CAS[154589-96-5] | Semi-synthetic

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Stauprimide, Streptomyces sp., | CAS[154589-96-5] | Semi-synthetic

品牌：AG Scientific

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规格：0.5 mg

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CAS:154589-96-5Formula:C35H28N4O5MW:584.6Appearance:YellowOrangeSolidPurity:98%byTLC

商品详情参考文献相关资料

Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as a potential antitumor agent. More recently, stauprimide has been shown to increase the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

Additional Information

Synonyms	N-Benzoyl-7-oxostaurosporine
Product #	S-2092
CAS #	154589-96-5
Chemical Name	N-((5S,6R,7R,9R)-6-METHOXY-5-METHYL-14,16-DIOXO-5,6,7,8,9,14,15,16-OCTAHYDRO-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-7-YL)-N-METHYLBENZAMIDE
Formula	C₃₅H₂₈N₄O₅
MW	584.6
Appearance	Yellow Orange Solid
Purity	98% by TLC
Solubility	Soluble in methanol, ethanol, DMF or DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression in certain cancers

Additional Information

MDL Number	MFCD14635443
ChemACX	X1763223-8
InChI	InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1
SMILES	C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

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