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PYR-41 |产品详情|进口橙子视频旧款采购网




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    订购信息
    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    PYR-41
    品牌:AG Scientific
    货号:
    规格:5 mg
    货期:

    CAS:418805-02-4Formula:C17H13N3O7MW:371.3Appearance:BrownSolidPurity:98%byTLC

    商品详情 参考文献 相关资料
    Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC< 10M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-B activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

    Additional Information

    Synonyms4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
    Product #P-2410
    CAS #418805-02-4
    Chemical Name4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
    FormulaC17H13N3O7
    MW371.3
    AppearanceBrown Solid
    Purity98% by TLC
    SolubilityDMSO (~25 mg/ml)
    Melting Point258.53 °C
    Storage Temp-20°C
    Therapeutic AreaOncological Disorders
    UsePYR 41 is an irreversible and cell-permeable UBE1 (ubiquitin-activating enzyme E1) inhibitor as therapeutics in cancer

    Additional Information

    MDL NumberMFCD01469983
    ChemACXX3304879-0
    InChIInChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
    SMILESCCOC(=O)c1ccc(cc1)N2C(=O)/C(=C\c3ccc(o3)[N+](=O)[O-])/C(=O)N2
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