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L-Buthionine-(S,R)-Sulfoximine

品牌：AG Scientific

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规格：1 g

货期：

应用：

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CAS:83730-53-4Formula:C8H18N2O3SMW:222.307Appearance:WhiteSolid

商品详情参考文献相关资料

Buthionine sulfoximine (BSO) is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis.

Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.

Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.

Additional Information

Synonyms	BSO, (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Product #	B-1081
CAS #	83730-53-4
Chemical Name	(2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Formula	C₈H₁₈N₂O₃S
MW	222.307
Appearance	White Solid
Solubility	Soluble in water (>25 mg/mL), aqueous acid, and 1N HCl.
Melting Point	210 - 213‚°C (dec.)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on tumor cells

Additional Information

MDL Number	MFCD00067000
ChemACX	X1014401-7
InChI	InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
SMILES	CCCCS(=N)(=O)CC[C@@H](C(=O)O)N

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