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Gliotoxin

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:67-99-2Formula:C13H14N2O4S2MW:326Appearance:WhitepowderPurity:>99%byHPLC

商品详情参考文献相关资料

*Please inquire the availability for this product. Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin inhibits a broad range of unrelated mechanisms, including inhibition of chymotrypsin-like activity of the 20S proteasome and Ca2+ release from mitochondria, activation of transcription factor NF-αÂºB in response to a variety of stimuli in T and B cells, anti-inflammatory activity, and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction with proteins through mixed disulphide formation. Gliotoxin inhibits a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.

Additional Information

Synonyms	Aspergillin, SN 12879, SN 12870
Product #	G-2521
CAS #	67-99-2
Formula	C13H14N2O4S2
MW	326
Appearance	White powder
Purity	>99% by HPLC
Solubility	Soluble in DMSO (10 mg/ml), methanol (10 mg/ml), chloroform (10 mg/ml), DMF, and Pyridine
Storage Temp	4°C
Use	A toxic epipolythiodioxopiperazine metabolite that induces apoptosis and inhibits NF-kB

Additional Information

MDL Number	MFCD00058534
InChI	InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
SMILES	CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O

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