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TNF-α Inhibitor

品牌：AG Scientific

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规格：5 mg

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CAS:1049741-03-8Formula:C32H32F3N3O2 2HCI•1/2H2OMW:629.6Appearance:WhiteSolidPurity:≥95%byHPLC

商品详情参考文献相关资料

A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC₅₀= 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC₅₀= 4.6 μM).

Additional Information

Product #	T-1252
CAS #	1049741-03-8
Chemical Name	6,7-Dimethyl-3-((methyl-(2-(methyl-(1-3-trifuluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCI, Tumor Necrosis Factor-α Inhibitor
Formula	C₃₂H₃₂F₃N₃O₂2HCI •1/2H₂O
MW	629.6
Appearance	White Solid
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	-20°C