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Actinomycin D

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:50-76-0Formula:C62H86N12O16MW:1255.42Appearance:RedtoRed-orangecrystallinepowderPurity:99.3%

商品详情参考文献相关资料

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriosestatic in nature, especially towards gram negative bacteria. Actinomycin D was the first antibiotic shown to have anti-cancer activity.

Actinomycin is a clear, yellow liquid administered intravenously and most commonly used in the treatment of a variety of cancers. It is also used as a radiosesensitizer in adjunct to radiotherapies since it can increase the radiosesensitivity of tumor cells, by inhibiting repair of sublethal radiation damage and, delay the onset of the compensatory hyperplasia that occurs following irradiation.

In cell biology, actinomycin D is shown to have the ability to inhibit transcription, this occurs by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.

Additional Information

Synonyms	Actinomycin IV; Actinomycin C1; Dactinomycin; Cosmegen; Meractinomycin; NCI C04682; NSC 3053; Oncostatin K
Product #	A-1022
CAS #	50-76-0
Chemical Name	8-AMINO-N-(2-AMINO-4,6-DIMETHYL-3-OXO-PHENOXAZIN-1-YL)CARBONYL-N'-[8-AMINO-4,6-DIMETHYL-7-OXO-9-[[3,6,10-TRIMETHYL-7,14-BIS(1-METHYLETHYL)-2,5,8,12,15-PENTAOXO-9-OXA-3,6,13,16-TETRAZABICYCLO[14.3.0]NONADEC-11-YL]CARBAMOYL]PHENOXAZIN-1-YL]CARBONYL-4,6-DIME
Formula	C₆₂H₈₆N₁₂O₁₆
MW	1255.42
Appearance	Red to Red-orange crystalline powder
Purity	99.3%
Solubility	Clear orange solution at 50 mg/ml DMSO or 10 mg/ml MeOH
Melting Point	252 - 254°C
Storage Temp	Store desiccated at +4°C
Therapeutic Area	Oncological Disorders
Use	Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes

Additional Information

Merck Index	12.2867.1996
MDL Number	MFCD00005033
ChemACX	X1005390-0
InChI	InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
SMILES	C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C