PBIT, JARID1 lysine demethylase inhibitor |产品详情|进口橙子视频旧款采购网

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PBIT, JARID1 lysine demethylase inhibitor

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PBIT, JARID1 lysine demethylase inhibitor

品牌：AG Scientific

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规格：25 mg

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CAS:2514-30-9Formula:C14H11NOSMW:241.31Appearance:Off-whitesolidPurity:98%byTLCNMR(Conforms)

商品详情参考文献相关资料

PBIT (2514-30-9) is a potent and selective inhibitor of JARID1 (IC₅₀ = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.

Additional Information

Product #	P-3329
CAS #	2514-30-9
Chemical Name	2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Formula	C₁₄H₁₁N_{O_S}
MW	241.31
Appearance	Off-white solid
Purity	98% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Storage Temp	-20°C (des.)