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品牌：AG Scientific

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规格：5 mg

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CAS:608512-97-6Formula:C13H8N4OSMW:268.299Appearance:Solid

商品详情参考文献相关资料

PKR kinase inhibitor.

It is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus.

Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei. It has been observed that PKR inhibitor may protect cells against ER stress induced cell damage.

Additional Information

Synonyms	PKR inhibitor, RNA-Dependent Protein Kinase Inhibitor,
Product #	C-2547
CAS #	608512-97-6
Formula	C₁₃ H₈ N₄ O S
MW	268.299
Appearance	Solid
Solubility	Soluble in DMSO
Storage Temp	+4°C
Use	Inhibits RNA-induced PKR autophosphorylation

Additional Information

MDL Number	MFCD06735404
ChemACX	X1708484-3
InChI	InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
SMILES	c1cc2c(c3c1ncs3)/C(=C/c4cnc[nH]4)/C(=O)N2

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