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ABT-869

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:796967-16-3Formula:C21H18FN5OMW:375.41Appearance:CrystallineSolidPurity:99%

商品详情参考文献相关资料

ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, ICvalue of 4 nM), but has much less activity (ICvalues >1 M) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (ICvalues of 2, 4 and 7 nM for PDGFR, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM ICfor human endothelial cells).

Additional Information

Synonyms	Linifanib
Product #	A-2177
CAS #	796967-16-3
Chemical Name	N-[4-(3-AMINO-1H-INDAZOL-4-YL)PHENYL]-N'-(2-FLUORO-5-METHYLPHENYL)UREA
Formula	C₂₁H₁₈FN₅O
MW	375.41
Appearance	Crystalline Solid
Purity	99%
Solubility	DMSO
Melting Point	180-183 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Linifanib (ABT-869) is a structurally novel, potent inhibitor of receptor tyrosine kinases (RTK), vascular endothelial growth factor (VEGF) use in cancer

Additional Information

MDL Number	MFCD11840918
ChemACX	X1671178-1
InChI	InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
SMILES	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

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