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 Psicofuranine |产品详情|进口橙子视频旧款采购网




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    Psicofuranine
    品牌：AG Scientific
    货号：
    规格：1 mg
    货期：

    CAS:1874-54-0Formula:C11H15N5O5MW:297.3Appearance:Whitetooff-whitesolidPurity:≥98%(HPLC)
    商品详情 参考文献 相关资料

    Psicofuranine is a nucleoside antibiotic isolated from Streptomyces sp. S 2113.

    The mechanism of action of psicofuranine was studied by quantitative reversal of its antimicrobial action on Staphylococcus aureus. The inhibition can be effectively reversed by several compounds containing purine bases. The most effective reversing agents contained guanine, whereas adenine- and hypoxanthine-containing nucleosides and nucleotides were much less active. 

    The effects of the antitumor agent, psicofuranine, have been investigated in rats. Longer treatment produced significant decreases in phosphate uptake by host tissues. 

    Pscifuranine is antimetabolite of the purine biosesynthesis and inhibits xanthosine monophosphate(XMP) aminase.

     

    Product References

    • Mechanism of action of psicofuranine, Ladislav J. Hanka, Research Laboratories, The Upjohn Company, (1959)

    • Studies with Psicofuranine in the Tumor-bearing Rat, Wayne E. Magee and Floyd S. Eberts, Jr.,Biochemistry Research Section, (1961)

    • Inhibition of Parental and Mutant Xanthosine 5'-Phosphate Aminases by Psicofuranine, Shigezo Udaka and H.S. Moyed, The Journal of Biological Chemistry, vol. 238, no. 8, (1963)

    Additional Information

    SynonymsAngustmycin C, U-9586
    Product #P-2423
    CAS #1874-54-0
    Chemical Name9-½‚²-D-Psicofuranosyl-9H-purin-6-amine
    FormulaC11H15N5O5
    MW297.3
    AppearanceWhite to off-white solid
    Purity≥98% (HPLC)
    SolubilitySoluble in DMSO; poorly soluble in methanol
    Storage Temp-20°C

    Additional Information

    Merck Index14: 7923
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