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 FTY720 | CAS# 162359-56-0 | Aids Transplant survival | A.G. Scientific | The ef |产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
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    FTY720 | CAS# 162359-56-0 | Aids Transplant survival | A.G. Scientific | The ef
    品牌:AG Scientific
    货号:
    规格:5 mg
    货期:

    CAS:162359-56-0Formula:C19H33NO2.HClMW:343.9Appearance:CrystallineSolidPurity:98%

    商品详情 参考文献 相关资料

    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.

    Additional Information

    SynonymsFingolimod
    Product #F-1162
    CAS #162359-56-0
    Chemical Name2-AMINO-2-(4-OCTYLPHENETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE
    FormulaC19H33NO2.HCl
    MW343.9
    AppearanceCrystalline Solid
    Purity98%
    SolubilitySoluble in DMSO (10 mg / ml), 100% ethanol or Dimethyl formamide.
    Melting Point102-107 °C
    Storage Temp-20°C
    Therapeutic AreaNeurological Disorders
    UseFTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator for treating multiple sclerosis

    Additional Information

    MDL NumberMFCD00939512
    ChemACXX1494471-1
    InChIInChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
    SMILESCCCCCCCCc1ccc(cc1)CCC(CO)(CO)N.Cl
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