Mitomycin C,Stem cells reagent hESCs |产品详情|进口橙子视频旧款采购网

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Mitomycin C,Stem cells reagent hESCs

品牌：AG Scientific

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规格：2 mg

货期：

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CAS:50-07-7Formula:C15H18N4O5MW:334.3Appearance:Blue-VioletSolid.Purity:>99%

商品详情参考文献相关资料

Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.

Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria. Mitomycin c role in pluripotent stem cells research expands into the CRISPR/Cas9 revolution to permit efficient gene correction.

Additional Information

Synonyms	MMC, Mutamycin, Ametycin, Mitocin-C
Product #	M-1108
CAS #	50-07-7
Chemical Name	[(1AS,8S,8AR,8BS)-6-AMINO-8A-METHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2',3':3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYL CARBAMATE
Formula	C₁₅H₁₈N₄O₅
MW	334.3
Appearance	Blue-Violet Solid.
Purity	>99%
Solubility	Clear blue-violet solution at 10mg/ml in DMSO or CH3OH.
Storage Temp	Store desiccated at -20°C.
Therapeutic Area	Oncological Disorders
Use	A DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells use in cancer

Additional Information

Merck Index	13.6236[p.2001
MDL Number	MFCD00078109
ChemACX	X1004059-0
InChI	InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
SMILES	CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N