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FSG67, GPAT inhibitor

品牌：AG Scientific

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规格：50 mg

货期：

应用：

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CAS:1158383-34-6Formula:C16H25NO4SMW:327.44Appearance:WhitesolidPurity:98%byTLCNMR(Conforms)

商品详情参考文献相关资料

FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC₅₀ = 24 μM. It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity. FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY. FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.

Additional Information

Product #	F-2489
CAS #	1158383-34-6
Chemical Name	2-(Nonylsulfonamido)benzoic acid
Formula	C₁₆H₂₅N_O₄S
MW	327.44
Appearance	White solid
Purity	98% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml)
Storage Temp	RT (des.)