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PRT4165, E3 ubiquitin ligase inhibitor

品牌：AG Scientific

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规格：50 mg

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应用：

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CAS:31083-55-3Formula:C15H9NO2MW:235.24Appearance:YellowsolidPurity:98%byTLCNMR(Conforms)

商品详情参考文献相关资料

PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC₅₀ = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α. PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.

Additional Information

Product #	P-3327
CAS #	31083-55-3
Chemical Name	2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
Formula	C₁₅H₉N_O₂
MW	235.24
Appearance	Yellow solid
Purity	98% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming).
Storage Temp	RT (des.)